Arsenic in PDB 7nrp: The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg

The structure of The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg, PDB code: 7nrp was solved by C.Thorpe, J.Hardwick, M.A.Mcdonough, J.P.Hall, Y.R.Baker, A.H.El-Sagheer, T.Brown, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.17 / 2.67
Space group	P 61
Cell size a, b, c (Å), α, β, γ (°)	54.338, 54.338, 45.88, 90, 90, 120
R / Rfree (%)	17 / 19.1

The binding sites of Arsenic atom in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg (pdb code 7nrp). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total only one binding site of Arsenic was determined in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg, PDB code: 7nrp:

Arsenic binding site 1 out of 1 in the The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of The Crystal Structure of A Dna:Rna Hybrid Duplex Sequence Cttttctttg within 5.0Å range: probe atom residue distance (Å) B Occ A:As101 b:117.8 occ:0.71 AS A:CAC101 0.0 117.8 0.7 O2 A:CAC101 1.7 80.1 0.7 O1 A:CAC101 1.7 87.4 0.7 C1 A:CAC101 2.0 90.6 0.7 C2 A:CAC101 2.0 80.1 0.7 N7 A:A9 4.2 69.8 1.0 O6 A:G10 4.3 71.0 1.0 O A:HOH201 4.4 78.6 1.0 N7 A:G10 4.4 69.8 1.0 N6 A:A9 4.6 70.8 1.0

Y.R.Baker, C.Thorpe, J.Chen, L.M.Poller, L.Cox, P.Kumar, W.F.Lim, L.Lie, G.Mcclorey, S.Epple, D.Singleton, M.A.Mcdonough, J.S.Hardwick, K.E.Christensen, M.J.A.Wood, J.P.Hall, A.H.El-Sagheer, T.Brown. An Lna-Amide Modification That Enhances the Cell Uptake and Activity of Phosphorothioate Exon-Skipping Oligonucleotides. Nat Commun V. 13 4036 2022.
ISSN: ESSN 2041-1723
PubMed: 35821218
DOI: 10.1038/S41467-022-31636-2