Arsenic in PDB 8ttv: Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302)

The structure of Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302), PDB code: 8ttv was solved by Q.Guo, K.-E.Chen, B.M.Collins, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	42.91 / 2.00
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	37.965, 74.2, 105.189, 90, 90, 90
R / Rfree (%)	20.7 / 26.4

The binding sites of Arsenic atom in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302) (pdb code 8ttv). This binding sites where shown within 5.0 Angstroms radius around Arsenic atom.
In total 2 binding sites of Arsenic where determined in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302), PDB code: 8ttv:
Jump to Arsenic binding site number: 1; 2;

Arsenic binding site 1 out of 2 in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 1 of Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302) within 5.0Å range: probe atom residue distance (Å) B Occ A:As421 b:73.0 occ:1.00 AS A:CAF421 0.0 73.0 1.0 O1 A:CAF421 1.6 58.2 1.0 CE2 A:CAF421 2.0 52.6 1.0 CE1 A:CAF421 2.0 53.0 1.0 SG A:CAF421 2.3 37.6 1.0 CB A:CAF421 3.4 23.3 1.0 CA A:CAF421 3.7 22.9 1.0 O A:HOH729 4.0 35.1 1.0 N A:CAF421 4.1 28.0 1.0 O A:HOH752 4.1 37.1 1.0 OG1 A:THR420 4.2 24.5 1.0 CG A:LYS398 4.2 49.5 1.0 OE2 A:GLU397 4.4 71.5 1.0 C A:THR420 4.5 32.0 1.0 O A:LYS394 4.5 39.1 1.0 O A:THR420 4.5 33.5 1.0 CA A:ALA395 4.7 43.0 1.0 O A:MET417 4.8 25.8 1.0 CB A:LYS398 4.8 42.5 1.0

Arsenic binding site 2 out of 2 in the Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302)


Mono view


Stereo pair view

A full contact list of Arsenic with other atoms in the As binding site number 2 of Structure of SNX27 Ferm Complexed with FAM21A Repeat 20 (1289-1302) within 5.0Å range: probe atom residue distance (Å) B Occ A:As519 b:67.6 occ:1.00 AS A:CAF519 0.0 67.6 1.0 O1 A:CAF519 1.6 50.6 1.0 CE2 A:CAF519 2.0 58.7 1.0 CE1 A:CAF519 2.0 45.0 1.0 SG A:CAF519 2.3 34.0 1.0 CB A:CAF519 3.3 19.1 1.0 C A:CAF519 3.8 28.2 1.0 N A:GLU520 4.0 24.3 1.0 O A:CAF519 4.1 26.2 1.0 CA A:CAF519 4.1 26.9 1.0 CG A:GLU520 4.3 30.0 1.0 CA A:GLU520 4.4 24.9 1.0 O A:HOH778 4.6 29.9 1.0 CD A:ARG516 4.6 24.2 1.0 NE A:ARG516 4.6 33.2 1.0 CD1 A:TRP523 4.6 42.4 1.0 CZ A:ARG516 4.7 34.4 1.0 NH1 A:ARG516 4.7 29.9 1.0 O A:ARG516 5.0 18.4 1.0

Q.Guo, K.E.Chen, M.Gimenez-Andres, A.P.Jellett, Y.Gao, B.Simonetti, M.Liu, C.M.Danson, K.J.Heesom, P.J.Cullen, B.M.Collins. Structural Basis For Coupling of the Wash Subunit FAM21 with the Endosomal SNX27-Retromer Complex. Proc.Natl.Acad.Sci.Usa V. 121 41121 2024.
ISSN: ESSN 1091-6490
PubMed: 39116126
DOI: 10.1073/PNAS.2405041121